The Hotel Regina Cristina is located about 50 meters from the main square. Guests are less than five minutes from the Camerello and the Augustus Gardens. The Hotel Regina Cristina connects with the city by bus or cable car. Guests can take the ferry or the helicopter service back to the mainland.

The four floors of the Hotel Regina Cristina contain 55 rooms, available as singles, doubles, and triples. Guests can watch satellite television on LCD screens, lounge in the air conditioning, keep snacks in the refrigerator, and enjoy their private bathroom with hair dryer.

The Hotel Regina Cristina is a Neoclassical structure with a terraced garden and locally made ceramic accents. The house restaurant serves regional specialties and seafood dishes, while the American bar offers coffees, wine, and cocktails. The outdoor swimming pool is shaded by the garden. Meeting rooms are available, as is Internet for business guests. Overnight laundry service is available, and the front desk is open 24 hours a day.